Jacqueline Nairn

Dr. Jacqueline Nairn

Lecturer in Biochemistry

PhD - University of Stirling (1991)
BSc - University of Stirling (1988)

School of Biological & Environmental Sciences
University of Stirling
Stirling
Scotland, FK9 4LA

tel: +44 1786 467821
fax: +44 1786 467843
email: Jacqueline Nairn

Research Interests

 

 

     Immune complexes in insects

 

     Activation of phenoloxidase

 

     Function of hemocyanin

 

     Regulation of human bisphosphoglycerate mutase

 

     Enzymes of central metabolism

 

     Use of protein engineering, biochemical and biophysical methods to understand

     protein structure and function

 

 

hemocyanin from limulus

 

       Structure of Limulus Hemocyanin

       (from Protein Data Bank code 1LL1 )

Research Students

Sharon Baird (2003-2007) A study of type-3 copper proteins from Arthropods

Christopher Coates (2009- ) Hemocyanin -  an essential component of arthropod immunity?

 

Teaching

           * Module coordinator

External Activities

Member of Biochemical Society (1988 - present)

Member of Institute of Biology (2009 - present)

Council member of Scottish Branch of Institute of Biology (2008 - present)

 

Current Publication List


Nicholas C. Price and Jacqueline Nairn (2009) Exploring Proteins, Oxford University Press
http://www.oup.com/uk/catalogue/?ci=9780199205707

Sharon Baird, Sharon M. Kelly, Nicholas C. Price, Elmar Jaenicke, Christian Meesters, Dorothea Nillius, Heinz Decker and Jacqueline Nairn (2007) 'Hemocyanin conformational changes associated with SDS-induced phenol oxidase activation' Biochimica et Biophysica Acta, Volume 1774, pages 1380–1394.

S. Uhrínová, D. Uhrín, J. Nairn, N.C. Price, L.A. Fothergill-Gilmore and P.N. Barlow Solution structure and dynamics of an open b-sheet, glycolytic enzyme, monomeric phosphoglycerate mutase from Schizosaccharomyces pombe. J. Mol. Biol. 306, 275-290 (2001)

D. Uhrín, S. Uhrínová, C. Leadbeater, J. Nairn, N.C. Price, P.N. Barlow 3D HCCH3 -TOCSY for resonance assignment of methyl-containing side chains in 13C-labeled proteins. J. Magn Resonance 142, 288-93 (2000)

J. Nairn, D. Duncan, N.E. Price, S.M. Kelly, L.A. Fothergill-Gilmore, S. Uhrínova, P.N. Barlow, D.J. Rigden and N.C. Price Characterisation of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase. Eur. J. Biochem. 267, 7065-7074 (2000)

S. Uhrin, D. Uhrin, J. Nairn, N.C. Price, L.A. Fothergill-Gilmore and P.N. Barlow (1999) The three dimensional solution structure of S.pombe phosphoglycerate mutase. In preparation.

R. Walter, J. Nairn, D. Duncan, N. C. Price, S. M. Kelly and L .A. Fothergill-Gilmore (1999) The role of the C-terminal region in phosphoglycerate mutase. Biochem. J. 337, 89-95

J. Nairn, D. Duncan, L.M. Gray, G. Urquhart, M. Binnie, O. Byron, L..A. Gilmore and N.C. Price (1998) Purification and characterisation of pyruvate kinase from Schizosaccharomyces pombe: evidence for an unusual quaternary structure. Protein Expression and Purification 14, 247-253

S. Uhrin, D. Uhrin, J. Nairn, N.C. Price, L.A. Fothergill-Gilmore and P.N. Barlow (1997) Backbone assignment of double labelled 23,7 Kda phosphoglycerate mutase from Schizosaccharomyces pombe. Journal of Biomolecular NMR, 10, 309-310.

J Nairn, N.C. Price, S.M. Kelly, D. Rigden, L.A. Fothergill-Gilmore and T. Krell (1996) Phosphoglycerate mutase from Schizosaccharomyces pombe; development of an expression system and characterisation of three histidine mutants of the enzyme. Biochim. Biophys. Acta 1296, 69-75.

Nairn, J., Price, N.C., Kelly, S.M., Rigend, D., Fothergill-Gilmore, L.A., Krell, T. (1996). Phosphoglycerate mutase from Schizosaccharomyces pombe - Development of an expression system and characterization of 3 histidine mutants of the enzyme. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology: 1296, 69-75.

Nairn, J., Smith, S., Allison, P.J., Rigend, D., Fothergill-Gilmore, L.A. and Price, N.C. (1996). Cloning and sequencing of a gene encoding pyruvate kinase from Schizosaccharomyces pombe - implications for quaternary structure and regulation of the enzyme. (vol. 134, 1995). FEMS Microbiology Letters: 136, 329

Nairn, J., Smith, S., Allison, P.J., Rigend, D., Fothergill-Gilmore, L.A. and Price, N.C. (1995). Cloning and sequencing of a gene encoding pyruvate kinase from Schizosaccharomyces pombe - Implications for quaternary structure and regulation of the enzyme. FEMS Microbiology Letters:134, 221-226.

Nairn, J., Krell, T., Coggins, J.R., Pitt, A.R., Fothergill-Gilmore, L.A., Walter, R. and Price, N.C. (1995). The use of mass spectrometry to examine the formation and hydrolysis of the phosphorylated form of phosphoglycerate mutase. FEBS Letters: 359, 192-194.

Nairn, J., Price, N.C., Fothergill-Gilmore, L.A., Walker, G.E., Fothergill, J.E. and Dunbar, B. (1994). The amino acid sequnce of the small monomeric phosphoglycerate mutase from the fission yeast Schizosaccharomyces pombe. Biochemical Journal: 297, 603-608.