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Dr. Tim WhalleyTeaching Fellow in Cell BiologyPhD - University
College, London (1990) School
of Biological & Environmental Sciences tel: +44 1786 467766 |
Research Interests
- My main research interests concern the mechanisms of intracellular membrane fusion, particularly during calcium-stimulated exocytosis, endocytosis and mitosis
My specific aim is to identify the minimum protein requirements for membrane fusion using cell-free reconstitutions and by perturbing protein function using specific probes such as neurotoxins
Teaching
Course coordinator for:-
- Cell Biology of Eukaryotic Cells (BIO1CB)
Recent Publications
Zimmerberg, J., Vogel, S.S., Whalley, T., Plonsky, I, Sokoloff, A., Chanturia, A. and Chernomordik, L.V. (1995). Intermediates in membrane fusion. Cold Spring Harbor Symposia on Quantitative Biology: 60, 589-599.
Whalley, T., Terasaki, M, Cho, M.S. and Vogel, S.S. (1995). Direct membrane retrieval into large vesicles after exocytosis in sea urchin eggs. Journal of Cell Biology: 131, 1183-1192.
Sokoloff, A.V., Whalley, T. and Zimmerberg, J. (1995). Characterization of N-ethylmalemide sensitive thiol groups required for the GTP-dependent fusion of endoplasmic reticulum membranes. Biochemical Journal: 312, 23-30.
The N-ethylmalemide sensitive protein thiol groups necessary for sea urchin egg cortical granule exocytosis are highly exposed to the medium and are required for triggering by Ca2+. Whalley, T. and Sokoloff, A. (1994). Biochemical Journal: 302, 391-396.
Suprynowicz, F.A. Prusmack, C. and Whalley, T. (1994). Ca2+ triggers premature inactivation of the CDC2 protein kinase in permeabilised sea urchin embryos. Proceedings of the National Academy of Sciences of the United States of America: 91, 6176-6180.
Sokoloff, A.V., Whalley, T. and Zimmerberg, J. (1994). Characterisation of thiol groups required for the GTP-dependent fusion of rat liver microsomes. Biophysical Journal: 66, A 284.
